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Globally, I believe [no current data to support this] that large doses of oral B12 have been used to some good effect, although it's not possible to work out who will benefit unless you do the experiment, and for that, if it meets the criteria of a clinical study, it needs [certainly in the UK] to be appropriately designed and reviewed before the work starts, and the results should be presented afterwards

Gastrointestinal absorption of vitamin B 12 depends on the presence of sufficient intrinsic factor and calcium ions

The Cochrane database of systematic reviews , (12), CD007769

Starter and tolerance0.25mg/wk The opening four weeks of any ladder

The green apple flavor adds a crisp and refreshing taste that enhances the overall experience