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Some studies claimed that cerebral endothelial tight junctions in fetal mouse and rat brain showed ultrastructural features such as the proportion of the junction composed of zonulae occludens which increased, while junctional clefts decreased, and expanded junctional clefts virtually disappeared (Stewart and Hayakawa, 1987, 1994)

Current research on TCM focuses on individual targets or pathways, aligning with the framework of modern medicine

Cytochrome P450 (CYP450) oxidoreductase can promote lipid peroxidation by accelerating the cycling between Fe 2+ and Fe 3+ in the CYP450 haem fraction and is identified as the alternative source of ROS that induces ferroptosis-related lipid peroxidation [70]

Zhang M, Jiao P, Wang X, Sun Y, Liang G, Xie X, Zhang Y (2022) Evaluation of Growth performance, nitrogen balance and blood metabolites of mutton sheep fed an ammonia-treated aflatoxin B1-contaminated diet

Yan, C., & Zhang, W