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Glutathione deficiency in cardiac patients is related to the functional status and structural cardiac abnormalities

Although a plethora of macrophage phenotypes has been identified by the advent of single cell biology - amongst others resident macrophages, TNF + pro-inflammatory macrophages, IL1 + pro-inflammatory macrophages, Trem2 + macrophages, lipid-associated Trem2 hi-perilipin + macrophages, and IL10 + TNFAIP3 + macrophages (de Winther et al., 2023

Glutathione's anti-inflammatory properties may help soothe irritated skin and reduce redness, promoting a more even complexion

Gln67 of TNF- also donates an h-bond to the carbonyl of VNAR-C4 Thr89, forming a backbone-backbone interaction common among VNARs 24

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