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Quantification of images was performed by a blinded investigator

In 2013, a Cochrane review of six studies found that taking folic acid or folinic acid reduced the proportion of people on methotrexte experiencing stomach problems (from 35 percent to 25 percent), abnormal liver tests (from 21 percent to 5 percent), and mouth sores (from 22 percent to 16 percent, which was not a statistically significant difference)