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If oral B12 replacement has been trialled in a person with metformin-associated B12 deficiency, I would suggest that a repeat measurement of B12 levels after 812 weeks is a good time to reassess whether absorption is adequate or whether a switch to intramuscular replacement is required

Rosenbloom AL (2015) A half-century of studies of growth hormone insensitivity/Laron syndrome: a historical perspective

All one carbon metabolism (methylation) reactions occur within mitochondria

When there is excessive bone growth on the edge of a bone, its surroundings can become compressed by the new bone, and this can cause a number of issues felt throughout the body