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In animal reproduction studies, intravenous administration of pemetrexed to pregnant mice during the period of organogenesis was teratogenic, resulting in developmental delays and increased malformations at doses lower than the recommended human dose of 500 mg/m2

[50] developed a curcuminanalogue nanoscavenger (NanoCA) by selfassembling CA with COOHPEGCOOH via reprecipitation to yield a PEGmodified puredrug nanoformulation (Fig

Early studies of oral contraceptives (birth control pills) containing high doses of estrogen indicated adverse effects on folate status