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TB-500: The Diagnostic Discrepancy of the Fragment An accurate clinical analysis of TB-500 requires a strict, uncompromising differentiation between the synthetic heptapeptide fragment (TB-500) and the naturally occurring, full-length 43-amino-acid parent protein (Thymosin Beta-4, or T4)

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However, this is a classic example of correlation being mistaken for causation: dark circles are common even in perfectly healthy individuals