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Bazzato G, Coli U, Landini S, et al

Self-emulsifying drug delivery systems (SEDDSs) can improve both solubility and permeability by increasing lipophilicity and facilitating intestinal transport

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9 Conclusion Intestinal ischemiareperfusion (I/R) injury affects the brain through systemic inflammation, gut microbiota dysbiosis, oxidative stress, and vagus nerve activation, leading to BBB disruption and cognitive impairment