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Calpain determines the propensity of adult hippocampal neural stem cells to autophagic cell death following insulin withdrawal

Hepatobiliary Pancreat Dis Int 11:6673 Katsikantami I, Sifakis S, Tzatzarakis MN, Vakonaki E, Kalantzi OI, Tsatsakis AM, Rizos AK (2016) Review article a global assessment of phthalates burden and related links to health effects

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johnsonii , is decreased in late-stage CKD patients and in CKD rats induced with 5/6 nephrectomy (NX) or unilateral ureteral obstruction (UUO), showing a negative correlation with serum creatinine ( Table 1 ) [106]

Over the last two and half decades, many efforts have been made on developing and implanting in vitro protocols to successfully differentiate hPSCs into insulin-producing -cells with key features of bona fide mature -like cells using multi-stages directed differentiation protocols that recapitulate and phenocopy all specific stages of pancreas embryogenesis ( However, many protocols developed to differentiate stem cells into insulin-expressing -cells in vitro have faced a roadblock: the resulting -cells often exhibit an immature phenotype with impaired glucose-stimulated insulin secretion (GSIS) compared to cadaveric islets