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Cardiovascular outcomes, long-term efficacy and safety In people with T2D and established cardiovascular disease, the international guidelines for T2D recommend the use of GLP-1 RA or sodium glucose co-transporters 2 inhibitors (SGLT-2i) as first-line treatment (independent of HbA1c), based on multiple trials demonstrating their cardio-renal benefits [109]

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Third, institutional and governance transformations are needed to create a more efficient, transparent, and inclusive management of maritime utilization . (Translated from Indonesian to English by the main author) 3.2 Six strategic issues of Indonesias ocean governance Despite the vast potential of its ocean resources and its advantageous position as the largest archipelagic state, some identifiable, recurring, and complex problems (Government of Indonesia, 2017b) have impeded Indonesias ability to become a strong maritime nation (Setiadi and Habil, 2022)

Pediatr Nephrol 14:3638

As the disease is incurable and death inevitable 35 years after the diagnosis, more extensive investigations are required in order to discover potential novel early biomarkers and therapeutics