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Overall, oral GABA intake appears to offer sleep benefits by enhancing relaxation and potentially alleviating sleep disturbances (Abdou et al., 2006)

In an in vivo study, curcumin failed to establish detectable plasma levels even at an oral dose of 180 mg 63

Overexpression of NRF2 in DCs leads to the inhibition of DC maturation and subsequently reduces effector T-cell activation, which may be related to the decrease in ROS levels mediated by NRF2

The AhR, a crucial sensor of environmental signals, participates in the DNA damage process through multiple mechanisms upon activation: By directly upregulating the expression of metabolizing enzymes such as cytochrome P450s (CYP1A1, CYP1B1) and aldo-keto reductases (AKRs), AhR promotes the metabolic activation of procarcinogens like polycyclic aromatic hydrocarbons (PAHs) (Shen et al., 2005

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