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Molecular and pathophysiological relationship between obesity and chronic inflammation in the manifestation of metabolic dysfunctions and their inflammationMediating treatment options (Review)

The selective depletion of GSH in this organelle can sensitize hepatocytes to the oxidative effects of cytokines such as tumor necrosis factor (TNF) [85]

ALS as a metabolic iceberg ALS may also be conceptualized as a metabolic iceberg, with the hallmark clinical, anatomical, and pathological features emerging as late-stage effects of impaired mitochondrial biology (Fig