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Subsequently, loser cells may undergo apoptosis

Y., & Ahirwar, D

doi: 10.1016/j.neulet.2022.136622 80 SharmaA

Metabolic products such as lactate produced by neutrophils through aerobic glycolysis can reversely amplify macrophage M1 polarization and the release of pro-inflammatory mediators, forming a immune infiltration - metabolic abnormality - inflammation amplification feedback loop to indirectly promote metabolic reprogramming (48, 53, 54)