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however, these medications have the potential to develop microbial resistance over time [275]

If the immune system were overactive then people with these conditions would not be getting microbial diseases

Bode BP, Fuchs BC, Hurley BP, Conroy JL, Suetterlin JE, Tanabe KK, et al

Psychoneuroendocrinology (2011) 36:25865.10.1016/j.psyneuen.2010.07.016 174 KamaliMSaundersEFProssinARBruckschCBHarringtonGJLangeneckerSAet alAssociations between suicide attempts and elevated bedtime salivary cortisol levels in bipolar disorder