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In this meta-analysis, four clinical trials and three cohort studies containing 825 hospitalized patients are retrieved

Therefore, it may be safe to draw a conclusion that Nrf2 has the capacity to regulate lipid peroxidation and ferroptosis via multiple mechanisms

We have no actual safety data, those studies havent been done and wont be done due to ethical issues

Li FY, Chaigne-Delalande B, Kanellopoulou C, Davis JC, Matthews HF, Douek DC, Cohen JI, Uzel G, Su HC, Lenardo MJ (2011) Second messenger role for Mg2+ revealed by human T-cell immunodeficiency

The main component of ASA, amygdalin, not only inhibits excessive oxidative stress and reduces the levels of liver injury-related enzymes, but also suppresses the production of TNF-, IL-6 and IL-1 as well as the expressions of inflammation-related proteins such as iNOS and COX-2, thereby mitigating inflammatory response and providing resistance against acute liver injury (Tang et al., 2019)