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Their inclusion here is intended to highlight future therapeutic directions rather than established EV-based pathways

The second co-stimulatory signal arises from the engagement of B7.1 (CD80) and B7.2 (CD86) molecules on APCsincluding activated macrophages, dendritic cells, and B cellswith CD28 on T cells

Figure 2: Glutamate is derived from glutamic acid from digested proteins, free glutamic acid, and glutamate salts such as MSG and MPG

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Recktenwald SM et al (2022) Cross-talk between red blood cells and plasma influences blood flow and omics phenotypes in severe COVID-19