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Allosteric Bcr-Abl Inhibitor ABL001 Overcomes Bcr-Abl Tyrosine Kinase Inhibitor Resistance and Enhances MDM2 Inhibitor CGM097 Activity in Blast Crisis CML Cells

Li M, Ching TH, Hipple C, Lopez R, Sahibzada A, Rahman H

Astrocyte senescence promotes glutamate toxicity in cortical neurons

SPS patients had decreased inhibition and markedly increased facilitation at short intervals pointing to motor cortex hyperexcitability owing to impaired supraspinal GABA-ergic neurons that lead to imbalance between inhibitory and excitatory intracortical circuitry

They have many beneficial traits that make them appealing, such as high stability for long-term storage, easy synthesis for efficient production, and better drug absorption than traditional formulations [164, 165]