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Yet, despite its importance, many of us may not fully understand how long-term supplementation of this powerful compound can impact our health

Why it matters: For patients with chronic joint pain, tendonitis, gut inflammation, or post-surgical inflammation, this means less swelling, better circulation, and faster repair

The T161 of DOR, located in the second intracellular loop and equivalent to the T180 of MOR, also plays a role in DPDPE-induced desensitization

Only a small part of patients experienced a flare after the initial improvement (103, 104)