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There are also several other underappreciated cerebellar afferent pathways (e.g., cerebellar connections with the brainstem nuclei [32]) and efferent connections (e.g., from the periaqueductal gray [33]) that we will not discuss here, but suffice it to say that cerebellar stimulation almost certainly affects many more circuits than the output pathways to the thalamus

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These data anchor the exercise-mimetic label in mechanistic and phenotypic readouts encompassing gene expression, mitochondrial content, fiber identity, and performance