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[1] Those who cannot digest or absorb B12 as a result of inherited genetics or damage to the stomach and small intestine require more than can be absorbed from sublingual supplementation

As such, while in vitro investigations provide important mechanistic insights, their results cannot be directly generalised to pharmacological or clinical implications without rigorous validation

The severity and persistence of the symptoms will inform the timeline because of these and other factors

These include systemic medications such as methotrexate, cyclosporine, retinoids, 6-thioguanine, mycophenolate mofetil, troglitazone, and new biologic agents like adalimumab, alefacept, efalizumab, etanercept, and infliximab, as well as topical therapies like steroids, vitamin D analogues, psoralen, 5-aminolevulinic acid, salicylates, fumaric acid esters, anthralins (dithranol), tacrolimus, and retinoids, such as tazarotene

In this context, we review existing literature on the association between fungi and cancer development to provide a comprehensive insight into the possibility of combining antifungals with other therapies for more effective cancer treatment