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Fatigue combined with cold intolerance and brain fog warrants measuring Free T3 rather than TSH alone. The obese trial cohorts lost roughly 8% of body weight at 1 mg in Phase 2 and about 28% at 12 mg in the 80-week Phase 3 trial

This approach provides initial therapeutic momentum while establishing a sustainable long-term strategy

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The supernatant was filtered using a 0.45-m filter before being applied to a pre-equilibrated 5-mL StrepTrap column (Cytiva)

Weeks 1-2: Metabolic Initiation During the first two weeks, the primary changes occur at the cellular level and may not be subjectively noticeable