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PEGylation is used to increase molecular size and is often explored for its potential to extend peptide persistence in experimental systems

When looking at the percentage of participants that dropped out of the trial due to adverse effects, 2-6% of patients in the cagrilintide group discontinued treatment early while 7% of the participants receiving liraglutide discontinued treatment early, These findings were in comparison to only 3% of test subjects from the placebo group that discontinued treatment due to adverse events [1]

However, limitations include in vivo instability, reliance on biocompatible and robust carriers and restricted application procedures (local and direct)