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Symptoms might include fatigue, shortness of breath, rapid heartbeat, cognitive difficulties, unsteady movements, and numbness or tingling in hands and feet

doi: 10.1002/advs.202302519

Most current OA animal models, such as the DMM model or chemically induced models, can simulate cartilage damage in the short term but struggle to fully replicate the long-term cumulative multifactorial pathological changes of human chronic OA

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The mechanism through which COCs exert their therapeutic effects involves the suppression of ovarian activity, reducing the estrogen-induced production of prostaglandins and therefore tissue inflammation [59]