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Cobalamin [Cbl(I)] initially provides two electrons to the catalytic cycle, enabling the energy-dependent transfer of a methyl group from MTHF to Hcy

Special vitamin B12 requirements during pregnancy, breastfeeding and in old age Pregnant women and breastfeeding mothers also have a higher requirement and must pay particular attention to getting enough vitamin B12, preferably through their normal diet

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Ideally, it should be a combination of adenosylcobalamin and methylcobalamin, or hydroxocobalamin as this can be converted into the other two active forms of B12