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Not only that, but it also lowered levels of a biomarker used to measure the rate of bone turnover as well

In the case of CYP4A11, the exposure of HepG2 cells to a mixture of palmitic and oleic acid resulted in elevation of mRNA as well as protein expression of CYP4A11 and an increase in intracellular ROS content (Gao et al

High levels may indicate metabolic stress or a need for improved detoxification

Additionally, topiroxostat inhibits the ATP-binding cassette transporter G2 (ABCG2), which plays a key role in renal uric acid reabsorption and the secretion of uric acid from the intestines

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