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The PARP-dependent nuclear translocation of AIFM1 from mitochondria induces DNA breakage, ultimately leading to cell death through the formation of an AIFM1-MIF complex

[PubMed Citation] Fortin JL, Desmettre T, Manzon C, Judic-Peureux V, Peugeot-Mortier C, Giocanti JP, Hachelaf M, Grangeon M, Hostalek U, Crouzet J, Capellier G

The relationship between a pathogenic variant of ABCB4 and the progression towards fibrosis and cirrhosis of diseases such as PSC (primary sclerosing cholangitis) and PBC has been explored

doi: 10.1016/j.semcancer.2024.05.002 [DOI] [PubMed] [Google Scholar] 218.Lin M-T, Lin C-L, Lin T-Y, et al

While injectable treatments add volume and lasers improve texture, neither can physically remove or reposition tissue