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Post-transcriptional regulation of GCLM has been described with HNE, which increased the stability of GCLM mRNA by a mechanism that required de novo protein synthesis (Liu et al., 1998)

It also effectively controls blood glucose and lipid levels, improves renal function, inhibits ROS overproduction, protects mitochondria from damage, improves lipid deposition in renal tissues, and downregulates the expression of lipogenic proteins SEBP-1 and Adipose Differentiation-Related Protein (ADRP) in DKD mice (198)

It is used in studies focused on collagen synthesis, skin regeneration, and tissue repair

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(2006) observed the lack of difference in beef cattle average daily gain (ADG) during the growing phase after a period of RPM supplementation (Mepron) and assumed that possibly Met is not a limiting AA at this stage of development