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Loss of CD73 prevents accumulation of alternatively activated macrophages and the formation of prefibrotic macrophage clusters in irradiated lungs

Unconjugated bile acids are highly toxic, hydrophobic molecules that can damage cellular membranes if allowed to accumulate

Therefore, the abundance of SQSTM1/p62 protein could be used as a representative marker for the autophagic flux, where decrease of SQSTM1/p62 abundance is associated with autophagy induction and increased level correlates with autophagy inhibition[17] or deficiency[4,6]

Drastically Reduces prostate gland enlargement

10.1182/blood-2002-10-3173 36 BrockN.HilgardP.PohlJ.OrmstadK.OrreniusS