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447 Inhibiting sEH activity provided significant protection against islet cell damage and improved glucose homeostasis in streptozotocin-induced diabetes

NEM-treated GSTP1 was then reacted with -alkynyl-palmitoyl-CoA, -alkynyl-palmitate, or Li-CoA, and subjected to the click reaction

These bonds will be cleaved within the acidic environment in endosomes and lysosomes, which will expose the positively charged amino groups of the polymer backbone and trigger the influx of H + and Cl , resulting in the elevation of endosomal osmotic pressure and the inflow of H 2 O

Signs of stalled transport inside cells decreased , suggesting cargo was moving to its destination more effectively

10.1038/sj.onc.1206944 32 KurtovicS.GrehnL.KarlssonA.HellmanU.MannervikB