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Chronic ethanol exposure has been shown to induce changes in DNA methylation and histone modifications that affect gene expression related to synaptic plasticity (Legaki et al

Saiz-Sanchez, D., Ubeda-Baon, I., De la Rosa-Prieto, C

Biochem Biophys Res Commun 386(4):703708 Hgg D, Englund MC, Jerns M, Schmidt C, Wiklund O, Hultn LM, Svensson PA (2006) Oxidized LDL induces a coordinated up-regulation of the glutathione and thioredoxin systems in human macrophages

8 PHARMACOLOGIC TREATMENT OF CF Medication management in CF includes the use of CFTR modulators, mucolytics, bronchodilators, and antibiotics to improve mucus clearance and treat infection