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J Clin Invest 133(11):e165934 Flynn PJ, Koch PD, Mitchison TJ (2021) Chromatin bridges, not micronuclei, activate cGAS after drug-induced mitotic errors in human cells

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Furthermore, post-ischemic treatment with lumbrokinase not only induced FoxO1 deacetylation but also activated Sirt1, which markedly reduced apoptosis, inflammation, and oxidative damage while enhancing autophagic flux following myocardial I-R-injury

Whether a single drug or intervention targeting iron death can avoid, reduce or reverse AD requires substantial analysis