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Cytoflavin in the complex therapy of multiple sclerosis

superoxide anion radical (O2-), hydrogen peroxide (H2O2) and hydroxyl radicals (*OH) (28, 31) ( Fig

An upregulation of the Nox4 expression with downregulation of the catalase expression and/or activity in diabetes increases the hydrogen peroxide concentration which promotes retinal neovascularization through the VEGF signaling pathway [82]