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Additionally, the transcription factor FOXO1, a major regulator of metabolic reprogramming in NSCLC, plays crucial roles in glucose metabolism, lipid oxidation, and cellular stress responses

Meanwhile, the broader senolytic field has advanced dasatinib+quercetin has completed multiple human trials including Phase 2 in Nature Medicine (Farr 2024)

B 83 , 157395 (2008)

48 MiR-128-3p simultaneously inhibits the expression of AXIN1, SFRP2, and WIF1 to enhance the activity of the Wnt/-catenin signalling pathway, thus promoting non-small cell lung cancer (NSCLC) metastasis

Lanosterol has been found to inhibit transmembrane protein 175 (TMEM175), a lysosomal proton export channel, and its clearance via CYP51A1-dependent metabolism restores TMEM175 function, thereby dampening lysosomal alkalinization and mitigating the induction of alkaliptosis [68]

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