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The genes normal function may be altered if it produces too many copies of itself (a process known as gene amplification) or too many copies of HER2 receptors (overexpression)

In very mild toxicity, only a fine tremor will be present, but in more advanced poisoning, fasciculations, hyperreflexia, dysarthria, and nystagmus may be seen as well (46)

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PE affects 38% of all pregnancies, with a disproportionately higher prevalence and mortality observed in low- and middle-income countries, where it accounts for 926% of maternal deaths 2,4