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In this 2008 study, intrathecal (i.t.) administration of ALX5407 (doses of 10, 50, and 100 g) resulted in significant analgesic effects, with an increase in mechanical pain thresholds observed up to 240 min after administration

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However, unexpectedly, K87pAcF showed the lowest stability among all the variants with the Tm value of 44.4 C, although it was predicted to be more stable than the wild type

Therefore, targeting DTP cells is anticipated to provide new treatment opportunities for cancer patients, although our current knowledge of these DTP cells in treatment resistance remains limited