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& O'Connor, M.J

Noble GT, Stefanick JF, Ashley JD et al (2014) Ligand-targeted liposome design: challenges and fundamental considerations

The subsequent release of oxidized metabolites further impairs cellular metabolism by inhibiting glycolysis, ultimately accelerating the progression of ferroptosis (Yagoda et al., 2007)

These effects are partly mediated by suppression of nocturnal cortisol and restoration of the physiological melatonin-insulin rhythm, which is often blunted in PCOS due to circadian misalignment (200)