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The resulting oxidative stress damages cellular proteins, lipids, and DNA, creating a vicious cycle that exacerbates neuronal degeneration (Fig

(3) OV Korkushko, BA Lapin, ND Goncharova, VKh Khavinson, et al (2007) (Normalizing effect of the pineal gland peptides on the daily melatonin rhythm in old monkeys and elderly people)