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parkeri cell-to-cell spread and plaque formation

PDEPT: polymer-directed enzyme prodrug therapy

Overproduction of hydrogen sulfide, generated by cystathionine beta-synthase, disrupts brain wave patterns and contributes to neurobehavioral dysfunction in a rat model of down syndrome

Notably, breast cancer cells achieve metabolic adaptation by hijacking the autophagy mechanism: under glucose-deprivation conditions, MANF-mediated mitophagy eliminates dysfunctional mitochondria through the PRKN/Parkin-dependent pathway, maintains the ATP supply and promotes tumour survival [112], suggesting that targeting the MANFPRKN interaction can break the drug resistance barrier of breast cancer under metabolic stress

baumannii treated with meropenem at lethal concentrations underwent morphological changes, with numerous cell walldeficient spherical cells observed under the microscope