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At the same time, HCY accumulates in the blood, leading to hyperhomocysteinemia

In practice with GHK-Cu: The copper dose delivered via typical topical or therapeutic administration is modest Short-term use has not been prominently associated with clinically significant zinc depletion Long-term or high-dose use warrants monitoring in patients where zinc balance is clinically important Patients with known zinc deficiency or on zinc-replacement should be monitored more closely A reasonable clinical approach: monitor copper and zinc status in patients on chronic GHK-Cu, particularly in symptomatic or long-duration protocols

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Wallace, K

If you are experiencing several of the signs listed below, it is worth having a private blood test to check your B12 levels before assuming deficiency is the cause