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When administered directly into the cerebrospinal fluid of mice, it showed dose-dependent pain-relieving effects that were blocked by naloxone, confirming involvement of opioid pathways

Science 298, 611615

Dimaras H, et al

Truy cp ngy 09/08/2023 Anna Pastore, Giorgio Federici, Enrico Bertini, Fiorella Piemonte (2003), Analysis of glutathione: implication in redox and detoxification ,pubmed.com