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Peptide degradation is cumulativea vial stored for three weeks at 6C has measurably lower potency than a freshly reconstituted batch, even if it hasn't reached the 30-day expiration threshold

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Grapefruit juice is a highly notorious and prototypical inhibitor of this metabolic pathway and its ability to wreak havoc with drug concentrations is well-documented

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J Cereb Blood Flow Metab 2007

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The methyl group transfer to the target molecule transforms SAM into S-adenosylhomocysteine (SAH), which subsequently undergoes a deadenylation reaction to yield homocysteine (23)

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