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Hypoxia-inducible microRNA-210 regulates the DIMT1-IRF4 oncogenic axis in multiple myeloma

We developed a wearable bracelet incorporating multi-array EMG, enabling patterns of forearm activity to be distinguished, and associated with functional modes or postures of the hand

In this way, the PGE 2 -Cav1.3-PARP1 axis forms a self-reinforcing survival pathway in which inflammation promotes Ca 2+ influx, and Ca 2+ influx supports anti-apoptotic signaling, allowing ectopic cells to evade clearance and persist in hostile microenvironments ( Therefore, targeting Ca 2+ signaling, particularly Cav1.3, may represent a dual therapeutic strategy by restoring mitochondrial resilience while also normalizing uterine contractility and pain-related signaling

CBS activity increases the flux via the transsulfuration pathway, which leads to GSH production, which becomes oxidized and depleted during oxidative stress