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Int J Paleopathol

The benefits of NAC have led to its inclusion in The World Health Organizations (WHO) list of essential medicines (53)

Note however that a well resolved viral infection, without associated persisting symptoms, also creates an immunological scar with persisting immune activation and increased cytokine production several months after symptom resolution (130, 131)

Indeed, the HF-AF ENERGY trial aims to assess whether nicotinamide riboside, an NAD+ precursor shown to be safe and to boost NAD+ levels in humans, can normalize blood-based markers of mitochondrial function and the NAD metabolome and, crucially, AF burden in the context of ischemic cardiomyopathy [98,99]