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By taking advantage of the cytoplasmic transmitochondrial hybrid (cybrid) cell model [46], it has been demonstrated that oestrogens reduce ROS production and limit apoptotic cell death by activating mitochondrial biogenesis in cells carrying LHON mutations, improving the metabolic defect [47]

Tissue, cell and stage specificity of (epi)mutations in cancers

OCD symptoms can sometimes be associated with other neurological conditions, such as stroke, brain tumor, trauma to the frontal lobe, Huntingtons disease, Tourettes syndrome, frontotemporal dementia, or hypoxia (Pallanti 2011

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