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Controlled study of induced granulomas treated with NAC showed 2-fold increase in GSH, 3-fold increase in Interferon-, 2- and 3-fold reduction in tumor necrosis factor- (TNF-) at 8 and 15 days, reduced reactive oxygen ions and reduced necrosis as compared to controls (68)

Induction of nitric oxide synthesis lowers intracellular glutathione in microglia of primary glial cultures

This process is regulated, as mTORC1-dependent phosphorylation of p62 increases its affinity for KEAP1, thereby activating NRF2 [85]

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