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On one hand, disturbances in cerebral energy metabolism can directly trigger or exacerbate neuroinflammatory responses [7]

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However, other studies have shown that TGF-1, through Smad3 activation, inhibits the expression of the glutamate-cystine antiporter system Xc-, enhancing lipid peroxidation levels in PLC/PRF/5, Huh7, Huh6, and Hep G2 cells marked by early TGF-1 genes, but not in cells marked by late TGF-1 genes [122]

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Research suggests that the sleep hormone melatonin also boosts glutathione status, this by stimulating production of the antioxidant enzyme glutathione peroxidase

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40,41 The Nrf2-keap1 pathway may be regulated through a variety of mechanisms

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Muscle satellite (stem) cell activation during local tissue injury and repair

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