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More specifically, a decrease in various cytokines such as interferon-gamma, IL-6, and IL-12p40 secretion, and an increase in IL-10 secretion was observed, along with low cell-activation status of antigen-presenting cells (APC) and an inhibition of IL-6 and IL-8 production by TLR2 and TLR4-stimulated monocytes in a dose-dependent manner

Cancer Cell 25 , 719734 (2014)

Any references to skin, collagen, extracellular matrix, or oxidative-stress pathways are provided only for research context and do not imply cosmetic or clinical use

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Adverse events Adverse reactions included pruritus, macular erythema, transient minute red spots on the skin, and tiredness