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The classification of hydrogels based on cross-linking methods, origins, and stimuli responsiveness is discussed, emphasizing their potential in drug delivery for dry eye disease (DED), glaucoma, corneal alkali burns, and neovascularization

LIST OF ABBREVIATIONS ALS Amyotrophic Lateral Sclerosis BBB Blood-brain Barrier CNS Central Nervous System DATS Diallyl Trisulfide DMC Dimethoxy Curcumin EGCG Epigallocatechin Gallate HT Hydroxytyrosol NO Nitric Oxide OS Oxidative Stress RNS Reactive Nitrogen Species ROS Reactive Oxygen Species RyR Ryanodine Receptors CONSENT FOR PUBLICATION Not applicable

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