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The concentrations, c , of samples with known standard additions (SA1 low, SA1 med, SA1 high) were calculated using Eq

The fitness score corresponding to FDR = 5% was determined to be 0.60, so that missense variants for which the upper end of the 95% confidence interval of their fitness scores was less than 0.60 were classified as deleterious variants

upon exogenous Mn 2+ loading, labile Mn 2+ becomes more broadly distributed, with increased signals observed throughout the cytosol and perinuclear regions in HeLa cells 82

In addition to this function, GPX4 regulates the mitogen-activated protein kinase/nuclear factor kappa-light-chain-enhancer of activated B cells (MAPK/NF-B) signal axis to prevent ECM degradation (Miao et al., 2022