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Oxido-reduction is not the only mechanism allowing ions traverse the ferritin protein shell

Because of hypoxia and acidosis in tissues and organs, reduced myocardial contractility, decreased arterial blood pressure, and reduced cerebral blood flow, some cells undergo primary death based on the severity and duration of HI

Although this trial did not demonstrate significant improvements in lung function, and the concomitant use of prednisone and azathioprine in that treatment arm actually worsened outcomes, N -acetylcysteine and other thiol-based antioxidants remain of interest as strategies to replenish intracellular glutathione in diseases such as COPD or cystic fibrosis, where they may mitigate oxidant-mediated macrophage dysfunction

Prolonged ER dysfunction triggers apoptotic and oxidative cell death pathways, reflecting the close coupling between redox regulation and protein quality control

Drug Discov Today 11(1920):931938 Wang Q, Yu X, Li L, Zheng J (2014) Inhibition of amyloid- aggregation in Alzheimers disease